The US and Mexican governments are currently negotiating a new water-sharing deal for the river basin, which supplies states in both countries.
In the midst of the region's worst drought in at least a decade, the two Andean nations are ramping up spending on water projects.
The loan will benefit over 165,000 households leaving in the vicinity of lake Titicaca.
Mexico's state oil firm says it will save nearly US$30mn a year over the next four years after revising procurement plan.
The portfolio includes four projects to supply potable water to the inhabitants of Honduras' central district, which is home to capital Tegucigalpa.
The authorities highlighted the importance of advancing the Porvenir and Penitente reservoirs in southern Chile.
The agreement was signed during the Budapest Water Summit 2016, which was organized by the World Water Council and the government of Hungary.
The US$75mn reservoir will serve the Petorca district in central Chile's Valparaíso region.
Of the producers included in the Nilo Coelho program, 86% (1,980) are small or family farmers owning up to 7ha of land.
Completion of the first phase of Santo Domingo's eastern aqueduct required a US$30mn investment. The project's second phase is scheduled to be completed next year.
The works will serve to compensate a potential loss of water supply in the municipality in case Conagua authorizes the construction of an aqueduct to send local water to a nearby thermal power plant operated by CFE.